Profhilo and Profhilo Structura Injections in Brașov

Discover hyaluronic acid injection services – Profhilo and Profhilo Structura – at ArtMedica in Brașov. Profhilo is an advanced hyaluronic acid bioremodeling procedure for deep skin rejuvenation and the restoration of facial volume lost with age.

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What is a Profhilo injection?

Profhilo is an injectable product developed by IBSA Derma, containing 64 mg of ultra-pure hyaluronic acid in a single 2 ml syringe. It is neither a classic filler nor a conventional skin booster – it is a tissue biostimulator that improves the firmness, elasticity, and hydration of the skin without altering facial volume or contours.

Its unique formula is based on the patented NAHYCO® technology, which combines high- and low-molecular-weight hyaluronic acid without the use of chemical cross-linking agents. Once injected, the product spreads evenly through the layers of the skin, drawing in water molecules for deep hydration and prompting fibroblasts to produce collagen and elastin – the proteins essential for skin firmness and elasticity.

Profhilo Structura is the second generation of this technology, launched in 2024. Unlike classic Profhilo, which acts at the level of the dermis, Profhilo Structura is formulated specifically to regenerate the subcutaneous adipose tissue – the deep fat layers of the face – which atrophy progressively with age, causing a “sagging skin” or “fallen face” appearance.

At ArtMedica, both treatments are available and can form part of a comprehensive protocol, tailored to each patient according to the stage of skin aging and facial volume.

What are the benefits of Profhilo and Profhilo Structura injections?

Profhilo – dermal bioremodeling

Deep, long-lasting hydration: The high concentration of hyaluronic acid attracts and retains water in the dermal layers, restoring suppleness and radiance to the skin.
Collagen and elastin biostimulation: By stimulating collagen and elastin production, Profhilo improves skin texture and elasticity gradually, with results that are both immediate and long-term.
Reduction of fine lines and improved texture: The skin takes on a smooth, even, and revitalized look.
No volume, no contour changes: The result is subtle and natural – the skin looks healthier, not treated.
Lasting results: Effects become visible 2–3 weeks after the first session, with collagen stimulation continuing over the following months.

Profhilo Structura – adipose tissue restoration

Rebuilding the facial fat compartments: The main areas targeted are the superficial medial and latero-temporal compartments of the cheeks – among the first affected by the aging process.
Natural lifting effect: The treatment improves the structure and support of the interstitial space, producing greater firmness and a lateral tightening effect across the face.
Documented increase in tissue thickness: Instrumental assessments recorded a significant increase in tissue thickness (+23%) and in hyperechoic fat zones, with no adverse events.
Persistent results: The benefits of the treatment are maintained over the long term once the treatment plan is complete.

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How is the Profhilo injection performed at the ArtMedica clinic?

At ArtMedica, the procedures are carried out exclusively by dermatologists, in a safe and controlled setting, following internationally validated clinical protocols. The procedure unfolds in the following steps:

Initial consultation: The doctor assesses skin quality, the degree of facial volume loss, and skin laxity. It is determined whether the patient will benefit from classic Profhilo, Profhilo Structura, or a combined protocol.
Preparing the area: The skin is cleansed and disinfected. A local anesthetic cream is applied, and around 30 minutes are allowed for it to take effect.
Injection technique: Profhilo is administered using the BAP technique (Bio Aesthetic Points), which involves five strategic injection points on each side of the face. These points were chosen for their anatomical safety and the product’s optimal capacity to spread. With just 10 injections per session, Profhilo achieves an even and effective distribution across the facial tissues.
Treatment plan: Two treatment sessions are recommended, 30 days apart, with a follow-up visit recommended 4 months after the first session.
Post-procedure care: Mild redness, minor bruising, or local swelling may appear – temporary reactions that resolve within 24–72 hours. It is advisable to avoid makeup for the first 12 hours, along with sun exposure and saunas for a few days, and to apply a product with a sun protection factor.

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Frequently asked questions about Profhilo and Profhilo Structura injections

1. What is the difference between Profhilo and skin boosters?

Profhilo is neither a classic filler nor a conventional skin booster. It is a tissue biostimulator — it acts deep within the skin, stimulating its own production of collagen and elastin rather than simply hydrating the surface. The result is an overall improvement in skin quality, not a volumizing effect.

2. What is the difference between Profhilo and Profhilo Structura?

Classic Profhilo acts at the level of the dermis, improving the skin’s hydration, texture, and elasticity. Profhilo Structura is the first product with a specific indication for regenerating subcutaneous adipose tissue — addressing the volume loss and the sinking of facial contours associated with aging, not just the quality of the skin’s surface.

3. How long do the effects last?

Clinical studies have shown that the clinical improvement in tissue thickness is maintained throughout a 6-month follow-up, for both Profhilo and Profhilo Structura. Longevity depends on age, lifestyle, and environmental factors.

4. Is the procedure painful?

Discomfort is minimal and short-lived. The anesthetic cream applied before the procedure significantly reduces any unpleasant sensations.

5. When do the results appear?

Visible improvements usually appear 10–15 days after the first session and are optimized after the second. The collagen biostimulation effect continues to develop over the following weeks and months. source

6. Can they be combined with other treatments?

Yes. Combining the two products – classic Profhilo for dermal bioremodeling and Profhilo Structura for adipose tissue restoration – can produce an overall regenerating and lifting effect. The doctor can integrate these treatments with Botulinum Toxin, laser therapies, or PRP, depending on the patient’s goals.

7. Are there any contraindications?

The treatments are not recommended for women who are pregnant or breastfeeding, for people with active infections in the treatment area (including active herpes), for those with uncontrolled autoimmune diseases, or for those with known allergies to hyaluronic acid or local anesthetics. A detailed medical consultation is required before any procedure.

8. How do I prepare before the treatment?

It is advisable to avoid alcohol, non-steroidal anti-inflammatory drugs, and aspirin in the days before the procedure, to reduce the risk of bruising. The skin should be clean and free of makeup on the day of the treatment. If you have a history of cold sores, let the doctor know in advance.

9. Who is Profhilo for, and from what age?

Profhilo is ideal both preventively and correctively – for people who want firmer, better-hydrated, healthy-looking skin without a volumizing effect. Profhilo Structura is intended for patients who already show signs of facial fat atrophy – usually from the age of 35–40 onward.

10. Which areas can be treated?

Profhilo can be applied to the face, neck, décolletage, and hands – any area where the skin shows dehydration, laxity, or loss of elasticity. Profhilo Structura is currently indicated exclusively for facial fat restoration, particularly the mid-face area. For areas such as the arms, abdomen, hands, and knees (areas where the skin frequently develops laxity, deep dehydration, and loss of firmness with age) Profhilo Body can be used.